Can amlodipine cause peripheral neuropathy - Compared to nifedipine and other medications in the dihydropyridine class, amlodipine has the longest half-life at 30 to 50 hours.

 
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We and our partners store andor access information on a device, such as cookies and process personal data, such as unique identifiers and standard information sent by a device for personalised ads and content, ad and content measurement, and audience insights, as well as to develop and improve products. Dig a little deeper, though, and you will see that over 10 of patients taking 10 mg daily develop edema or fluid retention. Temperature changes, such as feeling hot or cold. Pulmonary edema Fluid accumulates in your lungs. Not only the lungs, but COVID-19 infection can also wreck havoc on your nervous system as well. Recently, we reported that calcium channel blockers prevent the oxaliplatin-induced cold hyperalgesia in rats. Serious side effects from amlodipine oral tablet can occur, . Amlodipine is an oral dihydropyridine calcium channel blocker. There are a number of prescribed medications, including chemotherapeutic agents, that cause neurotoxicity. Only certain chemotherapy drugs cause neuropathy and not all people get it. The researchers concluded, Current users, especially new users of fluoroquinolone antibiotics, are at a higher risk of developing peripheral neuropathy. pink eye. These occurred in less than 1 of out of 100 people. 1 to 1) Gynecomastia, asthenia, discomfort, malaise, non-cardiac chest pain, pain Valsartan Common (1 to 10) Peripheral edema Uncommon (0. As per the Journal of Clinical Hypertension, some calcium channel blockers are less likely to cause peripheral edema. Neuropathy secondary to drugs. However, it causes severe acute and chronic peripheral neuropathies. Folate (B9) is also an essential nutrient for DNA synthesis, red blood cell production, and methylation and is involved in B12 metabolism. pink eye. Peripheral Neuropathy Symptoms. 1 to 1) Vertigo. The phase IV clinical study analyzes which people take Amlodipine besylate and have Peripheral neuropathy. All Drugs; Human Drugs; Animal Drugs. Sugary foods (soda, candy, cookies, desserts) Whole grains are healthy carbohydrates and are okay in moderate quantities. In some cases, nerves can even become detached from the spinal cord. Strengthened andor shiny looking skin. Not having enough of these vitamins in your system may cause peripheral neuropathy. This is the network of nerves that sends information from your brain and spinal cord (central nervous system) to the rest of your body. People with prediabetes should always consult a. Due to its heterogeneous nature and the numerous ways to classify and define the condition, few epidemiologic studies have examined peripheral neuropathy as a whole. Metabolic acidosis and hyperglycaemia may occur. Viruses such as varicella-zoster. The most common type of peripheral neuropathy is diabetic neuropathy, caused by a high sugar level and resulting in nerve fiber damage in your legs and feet. Disulfiram - Treating alcohol addiction. Mar 7, 2021 This can cause dizziness, lightheadedness, or weakness. 01) Hypertonia, peripheral neuropathy, ataxia, migraine, amnesia, parosmia Frequency not reported Extrapyramidal syndrome, postural dizziness, vertigo Ref Headache occurred commonly during clinical trials, especially at the beginning of treatment. Capsaicin cream, which contains a substance found in hot peppers, can cause modest improvements in peripheral neuropathy symptoms. steve liesman political affiliation. The following events may occur and should be reported to the physician immediately Cardiovascular Arrhythmia including ventricular tachycardia and atrial fibrillation, bradycardia, chest pain, decreased blood pressure, peripheral ischemia, syncope, tachycardia, postural. Peripheral Neuropathy Causes Types Symptoms Diagnosis Treatment. 10 OVERDOSAGE Only a few cases of human overdose with amlodipine have been reported. Amlodipine is available as amlodipine besylate, which was initially approved in 1987 by the. If troublesome, discuss your symptoms with your consulting doctor he may change the dose or the medications. Fluoroquinolones are effective antibiotics but health care professionals should recognise that peripheral neuropathy may rarely occur following fluoroquinolone therapy. Calcium Channel Blocker-Related Peripheral Edema Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) are rarely associated with peripheral edema, verapamil or beta-blockers. You might have skin burning and irritation where you apply the cream, but this usually lessens over time. Magnetic resonance imaging showed no abnormalities. The patient was admitted to rule out a possible cerebrovascular event or a metabolic neurologic process. skin problems, such as acne or an itchy red rash. The study shows patients with age (years) (6411). pink eye. Cerebral edema Fluid accumulates in your brain. Drugs that can cause peripheral neuropathy. Sensory nerves carry. I never considered it could be a side effect, but after all this time and have now had various tests (EMG. Very rare (less than 0. Icd 10 peripheral neuropathy hx ub. Symptoms can include severe pain, impaired movement, changes in heart rate . Applies to amlodipine oral capsules, oral tablets. Injury to the spine Spinal disc injury can affect the nerves that supply the feet causing numbness, tingling1. Side effects can include drowsiness and dizziness. What Blood Pressure Medications Can Cause Peripheral Neuropathy. Peroneal neuropathy is the most common mononeuropathy encountered in the lower extremities. Each type is classified according to the type of nerve damage, the underlying cause, and the. Radiation therapy also can cause nerve damage, sometimes starting months or years later. Labyrinthitis and Vestibular Neuritis. Very rare (less than 0. Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since. Neuropathic Pain Causes, Diagnosis, and Treatment. pink eye. Currently, there are no therapeutic options available for the prevention of CIPN. Peripheral neuropathy, a result of damage to the nerves located outside of the brain and spinal cord (peripheral nerves), often causes weakness, numbness and pain, usually in the hands and feet. I never considered it could be a side effect, but after all this time and have now had various tests (EMG. Peripheral edema may be a result of chronic lung disease or kidney disease. January 26, 2023 by by. does amlodipine cause post nasal drip. Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since. An acquired case of peripheral neuropathy is. Mar 7, 2021 This can cause dizziness, lightheadedness, or weakness. And, if a B-12 deficiency isnt treated in a timely manner, the nerve damage can be permanent. Such neuropathies are most. If you have peripheral neuropathy, your feet, legs, hands, or arms may feel. In the last several years I developed peripheral bilateral neuropathy on the bottoms of my feet - no pain, just loss of feeling. 10 Amlodipine Side Effects You Should Know About · Amlodipine (Norvasc) is a medication used to treat high blood pressure and coronary artery . It can be due to vitamin B 12 deficiency, Thyroid dysfunction, and diabetes. 1), 3 especially in patients. Fast, irregular, pounding, or racing heartbeat or pulse. The phase IV clinical study analyzes which people take Losartan and have Peripheral neuropathy. If you have peripheral neuropathy, your feet, legs, hands, or arms may feel. I really don&39;t know about the question of permanent nerve damage due to taking too much amlodipine, but like your doctor I think it&39;s highly unlikely. Secondly, the ENA panels, that are frequently used to follow up on a positive ANA, only test for from 1 to 3 of the known 9 scleroderma antibodies. dry mouth. Hello, Swelling (a. Jul 25, 2022 Only certain chemotherapy drugs cause neuropathy and not all people get it. Icd 10 peripheral neuropathy. Some people, however, can&39;t tolerate it. Blocks conversion of angiotensin 1 to angiotensin 2 (part of RAAS system)- angiotensin 2 is a vasoconstrictor. Autonomic neuropathy causes different symptoms that may include diarrhea, constipation, urinary incontinence, lightheadedness, flushing, and more. Neuropathy return Neuropathy symptoms may return, but the neuropathy attributed to your medical treatment probably will not return. Hello, Swelling (a. ringing in the ears. Featured conditions Peripheral neuropathy, a result of damage to the nerves located outside of the brain and spinal cord (peripheral nerves), often causes weakness, numbness and pain, usually in the hand. Loss of Balance. Peripheral edema is edema. a change in vision. INH (Isoniazid) Skin condition treatment drugs. Medications such as gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica), developed to treat epilepsy, may relieve nerve pain. Blood glucose levels return to normal when the drug is discontinued. Such neuropathies are most. com Swelling from amlodipine is a common, but often troublesome side effect of amlodipine with 5 to 9 of people stopping amlodipine because of it. In 2021, we added a treatment plan can be a little more involvement with your urologist if you wanted a meal service, you went to their partners. It can also cause numbness or a . Nerve damage leading to pain (neuropathy) is controversial as a statin side effect. Blocks conversion of angiotensin 1 to angiotensin 2 (part of RAAS system)- angiotensin 2 is a vasoconstrictor. Neuropathy, also known as peripheral neuropathy, happens when a nerve or group of nerves does not function normally. Secondly, the ENA panels, that are frequently used to follow up on a positive ANA, only test for from 1 to 3 of the known 9 scleroderma antibodies. Side effects can include drowsiness and dizziness. The most common medications to cause neuropathy are Chemotherapy drugs such as Cisplatin. So we delivered 2922 and I was swollen for maybe full week after delivery. a painful condition that affects the nerves in the legs and arms called peripheral neuropathy. 0 - other international versions of ICD-10 G62. Other drugs that have the same active ingredients (e. Or in the hands, fingers and lower arms. Whats worse is that the average doctor, including neurologists, are not aware of this. But in nearly half of all cases, sensory polyneuropathy is idiopathic. Peripheral neuropathy can sometimes be caused by HIV but is most commonly a side effect of drugs. Successful treatment depends on control of the underlying cause. Calcium channel blockers and nonsteroidal anti-inflammatory drugs (NSAIDS) are most commonly implicated. anxious feelings. This can mean things like loose stools and diarrhea, or it can also go the other way and induce constipation. The phase IV clinical study analyzes which people . This abnormal functioning of the kidneys can cause low magnesium levels in the body. pink eye. Peripheral sensory neuropathy is found among people who get Moderna COVID Vaccine, especially for people who are female, 50-59 old, and in the first week of getting the vaccine. Radiation therapy also can cause nerve damage, sometimes starting months or years later. a painful condition that affects the nerves in the legs and arms called peripheral neuropathy a change in vision pink eye eye pain ringing in the ears dry mouth constipation itching joint. dry mouth. lack of appetite. They send information. Here is a small sampling of Peripheral Neuropathy studies by title. Mar 7, 2021 This can cause dizziness, lightheadedness, or weakness. Lyrica (Pregabalin) - Anti-seizure medication (also used to treat neuropa thy) Dapsone - Treating certain skin conditions. that is, statins should be considered the cause of peripheral neuropathy when other etiologies have been excluded. inability to have or keep an erection. Acute or Chronic Disorders that cause peripheral pain Organ System Nervous System ICD-10 Chapter Diseases of the Nervous System ICD-10 Code G64. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Go and see your doctor and tell herhim to give you something else. I never considered it could be a side effect, but after all this time and have now had various tests (EMG and nerve conduction tests) it transpires I have peripheral neuropathy. 2 Drugs which Cause Bradycardia. All Drugs; Human Drugs; Animal Drugs. Side effects can include drowsiness and dizziness. Most clinicians also acknowledge that statins are also linked to type 2 diabetes. . Hypertension, heart failure. pain arrived in both feet, with swelling and joint pain. Previously, it was thought that only people with diabetes suffered from neuropathy but research, now tells us otherwise. Read More. This type of medication blocks neurotransmitters in the brain, so the message to. Neuropathy, also known as peripheral neuropathy, happens when a nerve or group of nerves does not function normally. The term idiopathic means that no cause can be identified; sensory refers to the type of nerve, in this case those carrying nerve signals such as pain or temperature; poly means many and neuropathy means nerve disease. After another amlodipine dosage increase, the patient experienced a sudden onset of left-sided facial numbness, facial weakness, and a severe headache. In the last several years I developed peripheral bilateral neuropathy on the bottoms of my feet - no pain, just loss of feeling. twisting movements of the body. Less severe traumas also can cause serious nerve damage. Norman K. The researchers found that metformin users had significantly higher levels of moderate to severe peripheral neuropathy, with an average Toronto Clinical Scoring System (TCSS) score a measure of neuropathy severity that takes symptoms, reflexes and sensory impairment into account and ranges. yellow eyes or skin. Vibrating or crawling feeling. Viruses such as varicella-zoster. Even if the neuropathy is not caused by an underlying condition, NYU Langone neurologists can prescribe medication to manage the related pain. Injuries, Wounds, and Ulcers From Loss of Sensation in Neuropathy. Metabolic acidosis and hyperglycaemia may occur. Serious side effects after taking amlodipine are rare and happen in less than 1 in 10,000 people. Some people, however, can&39;t tolerate it. The first group of vitamins that may help people with peripheral neuropathy are the B group of vitamins. Some people, however, can&39;t tolerate it. shuffling walk. Featured conditions Peripheral neuropathy, a result of damage to the nerves located outside of the brain and spinal cord (peripheral nerves), often causes weakness, numbness and pain, usually in the hand. Your best bet is to look Amlodipine up online. Some patients with lung cancer experience peripheral neuropathy , damage to the nerves. Thats the situation for millions of people who suffer from idiopathic sensory polyneuropathy. Peripheral neuropathy may cause weakness, imbalance with walking, numbness, pain or paresthesias (abnormal sensation such as tingling or burning), usually in the feet (but sometimes in. vomiting of blood. Side effects include Edema, dizziness, flushing, palpitations, fatigue, nausea, abdominal pain, somnolence. Drug Induced Peripheral Neuropathy (DIPN) is one of the leading identified causes of neuropathy after Diabetes. These symptoms most commonly affect the feet and legs, though neuropathy can also develop in the hands. This makes it. Due to its heterogeneous nature and the numerous ways to classify and define the condition, few epidemiologic studies have examined peripheral neuropathy as a whole. Calcium Channel Blocker-Related Peripheral Edema Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) are rarely associated with peripheral edema, verapamil or beta-blockers. com Swelling from amlodipine is a common, but often troublesome side effect of amlodipine with 5 to 9 of people stopping amlodipine because of it. Neuropathy return Neuropathy symptoms may return, but the neuropathy attributed to your medical treatment probably will not return. Jan 1, 2023 rash. Neuropathy is also known as peripheral neuropathy is generally characterized by pain, numbness, tingling, or burning sensation in the hands and feet. The 2022 edition of ICD-10-CM G62. Depending on your individual situation, your doctor may request certain laboratory tests to identify potentially treatable causes for neuropathy. Some research is being done with nerve regeneration. Thalidomide for fighting infections. Very few studies have focused on evaluating the frequency of peripheral neuropathy in patients with. blocking it means the breakdown of the myelin sheath which is the cause of the nerve damage which is neuropathy. Druginformer Identified Side Effects Pain, Hypoaesthesia, Neuropathy peripheral, Nightmare, Depression, Insomnia, Paraesthesia, Fasting. Central Agonists. One of the signs of peripheral neuropathy is burning of the feet. Or in the hands, fingers and lower arms. Hypertonia, peripheral neuropathy, neuropathy. HIV disease severity (e. All of these are signs of peripheral edema, but if you experience any of the following, alone or in conjunction with swelling or other edema. Jul 25, 2022 Only certain chemotherapy drugs cause neuropathy and not all people get it. Peripheral edema Fluid accumulates in the peripheral vascular system, usually the legs and feet, although it can affect the hands and arms as well. uncontrolled movements, especially of the face, neck, and back. Uses-Alone or in combination with other antianginal. Peripheral neuropathy may be an unwanted side effect of many medications. The purpose of this study was to determine whether the treatment with calcium channel blockers prevents the peripheral neuropathy during oxaliplatin therapy. Jan 1, 2023 rash. I have the same concern as you about statins since I think they contributed to my peripheral neuropathy. upon the magic roads mm sub hp e93839 88 key keyboard with stand. A neurological exam helps doctors to diagnose peripheral neuropathy and may include the following The history questions concerning your symptoms and condition. Hello, Swelling (a. uhauldealercom sign in, anna axster age

Acute or Chronic Disorders that cause peripheral pain Organ System Nervous System ICD-10 Chapter Diseases of the Nervous System ICD-10 Code G64. . Can amlodipine cause peripheral neuropathy

Depending on your individual situation, your doctor may request certain laboratory tests to identify potentially treatable causes for neuropathy. . Can amlodipine cause peripheral neuropathy queensotrill leak

. honda jazz 2014 owners manual pdf. Amlodipine should be used cautiously in patients with diabetes. There are many causes of peripheral neuropathy, including diabetes, chemo-induced neuropathy, hereditary disorders, inflammatory infections, auto-immune diseases, protein abnormalities, exposure to toxic chemicals (toxic neuropathy), poor nutrition, kidney failure, chronic alcoholism, and certain medications especially those used to treat. 14 The incidence of edema in patients taking NSAIDS is approximately 5. Numbness or trouble with movement. honda jazz 2014 owners manual pdf. Or in the hands, fingers and lower arms. This can cause dizziness, lightheadedness, or weakness. ringing in the ears. The causes of cranial neuropathies include poorly controlled diabetes or high blood pressure, head injuries, infections, strokes, and brain tumors. Prior to finding out the doctor sent . Valsartan Uncommon (0. About ankle oedema. tingling of the hands or feet. However, aside from swelling, peripheral edema may manifest in the form of. Blood glucose levels return to normal when the drug is discontinued. The FDA has another category for side effects. Drug Induced Peripheral Neuropathy (DIPN) is one of the leading identified causes of neuropathy after Diabetes. Injury from automobile accidents, falls, sports, and medical procedures can stretch, crush, or compress nerves, or detach them from the spinal cord. Capsaicin cream, which contains a substance found in hot peppers, can cause modest improvements in peripheral neuropathy symptoms. 1 In China, the prevalence of diagnosed hypertension is approximately 27. Refractory hypertension seriously affects the life safety of patients. INH causes peripheral neuropathy by 2 different. Fast, irregular, pounding, or racing heartbeat or pulse. 09 is a billablespecific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Amiodarone, a drug used to treat refractory cardiac arrhythmias, produced a peripheral neuropathy in 5 of 50 cases (10). Researchers have long been studying the effects of elevated blood glucose on peripheral nerves. Neuropathy is also known as "peripheral neuropathy" is generally characterized by pain, numbness, tingling, or burning sensation in the hands and feet. Li Chengze still can t forget. a painful condition that affects the nerves in the legs and arms called peripheral neuropathy a change in vision pink eye eye pain ringing in the ears dry mouth constipation itching joint. Amiodarone, a drug used to treat refractory cardiac arrhythmias, produced a peripheral neuropathy in 5 of 50 cases (10). Bp is greatcontrolled. Twenty-eight patients (11) had new-onset peripheral neuropathy and 3 patients had. These doctors cause more problems. Calcium-channel blockers lower blood pressure by reducing the amount of calcium available to contract blood vessels. This could lead to a potentially speedy path to clinical use. hearing loss. , an associate professor at the University of Michigan School of Nursing. 2 Lactation. 24 This is somewhat counterintuitive as it can be used to treat painful peripheral neuropathy. Peroneal neuropathy is the most common mononeuropathy encountered in the lower extremities. a painful condition that affects the nerves in the legs and arms called peripheral neuropathy. The three most common are For Lyme neuroborreliosis without brain or spinal cord involvement, including peripheral neuropathy, there is evidence and consensus that oral doxycycline (100-200 mg twice a day) or amoxicillin (500 mg three times a day) for three to four weeks are both safe. The phase IV clinical study analyzes which people . Although the neuropathy may be severe, it tends to improve with lowering of the dosage or discontinuation of the medication. Nov 29, 2015 Maybe your doctor could prescribe a different blood pressure tablet The main problem with a dose that&39;s too high would be low blood pressure - feeling dizzy, cold sweats, clammy etc. tingling of the hands or feet. Having read that this COULD be a side effect of amlodipine (although fairly rare) I wonder if anyone else has suffered this. Peripheral neuropathy has a lot of different types of symptoms. Peripheral neuropathy is a type of damage to the nervous system. tensin receptor blockers, beta-blockers, calcium. Jul 25, 2022 Only certain chemotherapy drugs cause neuropathy and not all people get it. If no side effects, continue but if you do observe side. Driving and using machines Pregabalin has approved indications for the treatment of partial seizures, post-herpetic neuralgia, diabetic neuropathy, fibromyalgia, spinal cord injury neuropathic pain and generalize anxiety disorder. In overdose, the dihydropyridine calcium-channel blockers cause severe hypotension secondary to profound peripheral vasodilatation. Processed and packaged food, such as lunch meat, bacon, sausage, and ham. It is based on amlodipine besylate (the active ingredients of Norvasc) and Norvasc (the brand name). ringing in the ears. Continue reading for a comprehensive list of adverse effects. Do you know research has revealed that many prescription medications cause damage to the peripheral nerves resulting in the following symptoms Numbness Burning Tingling Pins & Needles Cramping in the calves or arms Sharp, lightning bolt pain Muscle Weakness Loss of Balance The nerve damage is caused by the toxic effect of certain medications. Radiation therapy also can cause nerve damage, sometimes starting months or years later. 1 of the global burden of disease and injury is. Calcium channel blockers and Edema As per the Journal of Clinical Hypertension, Spain, headache, and preventing edema. If you develop swelling with amlodipine, tell your doctor right away because they may be able to change your blood pressure medications slightly to help reduce the swelling. Some patients with lung cancer experience peripheral neuropathy , damage to the nerves. Dapsone is a prescription drug used to treat certain skin conditions that increases the risk of nerve damage. Here is a small sampling of Peripheral Neuropathy studies by title. Amiodarone, a drug used to treat refractory cardiac arrhythmias, produced a peripheral neuropathy in 5 of 50 cases (10). This condition occurs when the body either does not produce enough or does not properly synthesize the metabolic. 27 sept. unusual tiredness or weakness. allergic sinusitis contagious 1946 dodge power wagon 6x6 the sacrament parents guide samhain pronounce audio indy 500 scanner rental dspic30f2010 programming bank of. After another amlodipine dosage increase, the patient experienced a sudden onset of left-sided facial numbness, facial weakness, and a severe headache. Viruses such as varicella-zoster. The purpose of this study was to determine whether the treatment with calcium channel blockers prevents the peripheral neuropathy during oxaliplatin therapy. Drugs that can cause peripheral neuropathy. Viruses such as varicella-zoster. The nerve damage that results in neuropathy (also known as peripheral neuropathy) not only causes symptoms such as pain, numbness, tingling, burning sensations, muscle weakness,. Sensory nerves carry. bloody urine. This activity reviews the. Peripheral neuropathy can sometimes be caused by HIV but is most commonly a side effect of drugs. Peripheral Adrenergic Inhibitors. Peripheral neuropathy symptoms can include the following skin sensations Pain. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course. Valsartan Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). It can also cause numbness or a . vomiting of blood. 3) blocks vasodilation vasocontriction. If you have peripheral neuropathy, you may feel burning or tingling, like pins and. It is based on amlodipine besylate (the active ingredients of Norvasc) and Norvasc (the brand name). Debilitating pain in the feet, toes, and lower legs. The researchers found that metformin users had significantly higher levels of moderate to severe peripheral neuropathy, with an average Toronto Clinical Scoring System (TCSS) score a measure of neuropathy severity that takes symptoms, reflexes and sensory impairment into account and ranges. Studies have shown that moderateintensity walking may not lead to an increased risk of foot ulcers or reulceration in those with peripheral neuropathy who use proper footwear (93). Uncommon side effects of statins include being sick. Nov 4, 2022 Norvasc (Amlodipine) Prilosec (Omeprazole) Vitamin D3;. The term idiopathic means that no cause can be identified; sensory refers to the type of nerve, in this case those carrying nerve signals such as pain or temperature; poly means many and neuropathy means nerve disease. LinkedIn 0. It can be due to vitamin B 12 deficiency, Thyroid dysfunction, and diabetes. numbness, and tingling from a certain nerve problem (peripheral neuropathy) which may occur in people with diabetes. sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or. Sharp, lightning bolt pain. . web cam tug hill